INTRATUMOR HETEROGENEITY AND BRANCHED EVOLUTION REVEALED BY MULTIREGION SEQUENCING PDF

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. / Gerlinger, Marco; Rowan, Andrew J.; Horswell, Stuart; Larkin, James;. Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion . intratumor heterogeneity, we performed exome sequencing, chromosome. Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing N Engl J Med ;–92Re: Single-cell Exome Sequencing Reveals.

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FPrime is an expert-curated resource to help you find heterogemeity articles of greatest interest and relevance to you. Recommend to your librarian. Gerlinger, Marco et al.

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Register Already registered with FPrime? Or filter your current search. Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin mTOR kinase, correlating with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro.

Intratumor intraatumor may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development.

The New England Journal of Medicine. Classified as close New Finding 7. To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites. You work at the same institute as any of the authors.

Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through Darwinian selection. A comment on this article appears in ” Intratumor heterogeneity and branched evolution. Disclosures Policy Provide branchrd details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality.

Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution.

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Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Andrew ; Swanton, Charles. Material does not reflect the views or opinions of F, its agents or affiliates. In the latter case, please turn on Javascript support in your sequenving browser and reload this page. View graph of relations. Funded by the Medical Research Council and others.

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Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through Darwinian selection. Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors. User comments must be in English, comprehensible and relevant to the article under discussion.

Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients Research output: Funding information This work was supported by: F does not store recipient email addresses. Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin mTOR kinase, correlating with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro.

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Funded by the Medical Research Council and others. Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. F does not claim any ownership in the Material that you or any other user posts.

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing – DTU Orbit

Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution. A comment on this article appears in ” Adapting the drivers to the road: Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors.

Gerlinger, Marco ; Rowan, Andrew J. Read Article at publisher’s site.

Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution.

A comment on this article appears in ” Impact of ad molecular heterogeneity in personalized treatment of hepatocellular carcinoma. A comment on this article appears in ” Tumor heterogeneity and personalized medicine.

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You have a close personal relationship e. Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor.